There are four major categories of leukemia triggered by the medical community in general. 1, viral factors The leukemogenic role of RNA tumor viruses in animals such as mice, cats, chickens and cattle has been confirmed, and most of the leukemias caused by such viruses are of the T-cell type. In recent years, human T-cell leukemia virus (HTLV), which is a C-type retrovirus, has been isolated from adult T-cell leukemia and lymphoma patients. However, no clear relationship between this type of virus and pediatric leukemia has been found. 2. Chemical factors Some chemicals have a leukemogenic effect. For example, the incidence of leukemia is higher in people exposed to benzene and its derivatives than in the general population. Reports of leukemia induced by nitrosamines, pautazone and its derivatives, chloramphenicol, etc. have also been seen, but there is a lack of statistical information. Certain antitumor cytotoxic drugs such as nitrogen mustard, cyclophosphamide, methylbenzylhydrazine, etc. are recognized to have leukemogenic effects. 3, radiation factors There is conclusive evidence that various ionizing radiation conditions can cause human leukemia, such as X-rays and r-rays. The occurrence of leukemia depends on the dose of radiation absorbed by the body, and leukemia can be induced by moderate or high doses of radiation to the entire body or part of the torso. However, it is still uncertain whether small doses of radiation can cause leukemia. After the atomic bombings in Hiroshima and Nagasaki, Japan, the incidence of leukemia in areas exposed to severe radiation was 17 to 30 times higher than in areas not exposed to radiation. Three years after the explosion, the incidence of leukemia increased year by year, reaching a peak at 5-7 years. It took until 21 years for its incidence rate to return to a level close to that of Japan as a whole. The incidence of leukemia increases significantly in radiation workers, those who are frequently exposed to radioactive substances. Receiving radiation diagnosis and treatment can lead to an increase in the incidence of leukemia. 4, genetic factors The incidence of leukemia is higher in people with chromosomal aberrations than in normal people. For example, the incidence of leukemia in children with trisomy 21 is 1/74 within 10 years of age, and the incidence of Fanconi syndrome is 1/12 within 21 years of age. when one member of the family develops leukemia, the chance of leukemia in the next of kin is more than 4 times higher than that of the general population. Recent studies have confirmed that abnormalities in the number of chromosomes, such as an increase or decrease in the number of chromosomes, and structural abnormalities, such as translocations, inversions and deletions, cause abnormalities in the structure and expression of genes. Gene expression and/or inactivation of genes is one of the bases of cellular malignancy. The causative agents (genetic factors) that lead to leukemia are beyond our control, but we can pay more attention to them in our daily work and do not expose ourselves too much to X-rays and other harmful radiation, and if we work with radiation, we should do a good job of personal protection. Women should stay away from radiation even more when they are pregnant, to give the baby the best advance protection work. Parents who work in heavy industries should try to minimize exposure to benzene and its related benzene substances. This is because chronic benzene poisoning mainly damages the body’s hematopoietic system, causing a decrease in the number of human white blood cells and platelets to induce leukemia. Provide an initial preventive work for your own children, which is also a kind of protection for yourself. If a baby is born, this is the time when we should do a better job of prevention of leukemia in children.