Posterior tibial vein thrombosis belongs to deep vein thrombosis, which is a kind of distal isolated deep vein thrombosis. In clinical some patients, the symptoms are not obvious or there is slight swelling and pain, and the patients do not care about it, but in the acute stage, the thrombus can also be dislodged and cause the risk of pulmonary embolism.1. Treatment in the acute stage: the patient should be advised to elevate and brake the affected limb, absolutely lie in bed, do not labor, massage, knead the affected limb, so as to avoid dislodging the thrombus and causing pulmonary embolism. Give the patient regular anticoagulation treatment, anticoagulant drugs can choose low molecular heparin, warfarin, rivaroxaban, dabigatranate and so on. The anticoagulation should be adequate and full course, at least three months to six months, and the medication should be adjusted according to the patient’s review. 2. Sub-acute and chronic stage: It can also be assisted with drugs to promote venous reflux to reduce swelling and wear medical compression stockings to relieve the edema and other symptoms caused by venous thrombosis. In the long-term follow-up process, it is important to pay attention to regular medication and regular observation to avoid serious complications such as post-thrombotic syndrome.