Unilateral numbness in the hands and feet is a precursor of stroke, which may occur or has already occurred, so it is important to see a hospital for timely examination and treatment. Bilateral numbness in the hands and feet is considered to be caused by peripheral neuritis, which can be seen in peripheral neuropathy and diabetic peripheral nerve injury. It is recommended that the patient consult a hospital for electromyography and give nerve-nourishing medication. If diabetes is the cause, it is crucial to control blood glucose and to achieve the blood glucose standard. Nerve nourishment can be done by taking oral methylcobalamin or epalrestat to nourish the nerves, or by using intravenous lipoic acid to nourish the peripheral nerves.