New crown and cold have many similar symptoms at the beginning, so it is easy to confuse, but there are still some obvious differences between the two in terms of symptoms, incubation period, causative agent, imaging performance, etc. The main differences are as follows: 1. symptoms: cold patients are prone to upper respiratory tract symptoms such as runny nose, sneezing, headache, dry throat, sore throat, itchy throat, no fever or only low fever. The new crown patients are more likely to appear dry cough, weakness, breathing difficulties and other lower respiratory symptoms, some patients will also be accompanied by abdominal pain, vomiting, diarrhea and other gastrointestinal symptoms, fever is mainly moderate, low fever, some patients even no fever phenomenon, can quickly appear sepsis, coagulation dysfunction, respiratory distress syndrome, shock, multi-organ function damage, etc.; 2, incubation period: cold incubation period is generally 1 -3 days, usually relatively short, while the new crown incubation period is longer, usually within 14 days, the average of 7 days; 3, the causative agent: cold is usually due to coxsackievirus, adenovirus, respiratory syncytial virus, influenza virus triggered, while the new crown is caused by coronavirus (2019-nCoV); 4, imaging performance: cold is an upper respiratory tract infection, the patient’s lungs are usually normal, while the new crown patients Most of them will show multiple small patchy shadows in early chest CT, and the outer lung bands are the most obvious, slowly developing into multiple ground glass shadows and infiltrative shadows in both lungs. In summary, neo-coronary and cold can be distinguished in many aspects. If patients have related uncomfortable symptoms, it is recommended to go to the hospital for blood routine, novel coronavirus nucleic acid test, lung CT examination, etc., in order to clarify the cause and then carry out targeted treatment.