1, the first time to take the cream formula 2, thick and greasy tongue, often bloating, indigestion and other digestive problems, if directly take the cream formula, but will increase the gastrointestinal burden, aggravate the symptoms 3, a variety of chronic diseases, such as hypertension, hyperlipidemia, stroke, diabetes, their conditions are more complex, need to use the open road formula to test their internal deficiency, and determine the focus of medication. 4, physical and mental diseases, such as anxiety, depression, sensitive and suspicious people, such people are more sensitive to drugs, clinically common in the process of eating cream discomfort reactions