Preface: In the dermatology clinic or urology clinic, there are often people who are nervous and preoccupied because of the pearly papules on the penis and suspect that they have warts. In fact, this condition may be pearly papules, not warts, and not even a disease. A few people also have 1 to 3 symmetrical similar papules on both sides of the foreskin tether. The pearly papules of the penis are characterized by the fact that they do not bleed when touched (condyloma acuminatum bleeds easily when touched), have no conscious symptoms and can last a lifetime. On pathological examination and etiology, penile pearly papules present as angiofibromas of the extremities, often occurring after puberty and decreasing in incidence with age. The age of occurrence of penile pearly papules ranges from 11 to 52 years, and they are more frequent in adolescents and young men. The presence of penile pearly papules does not seem to have a specific function and is currently not considered to be related to sexuality, but can be considered a residual human construct that evolved from animal ancestors, and is also considered by some scholars to be a normal variant. Therefore, penile pearly papules are a physiological variant, not a disease, and there is absolutely no need for treatment. It has been reported in the literature that 20% to 40% of men have pearly penile papules. The actual fact is that there are still a lot of people who know a lot about this, especially those who have a history of unclean sexual intercourse, often mistaking penile pearly pimples for condyloma acuminata, which causes great psychological fear. The actual fact is that you can find a lot of people who are not able to get a good deal on this kind of things. If you insist on treating penile pearly whites, you can use liquid nitrogen cryotherapy or laser treatment. Electrocautery, scraping or surgical excision are also treatment options, but they may cause small scars. If the patient is overcircumcised, laser excision will also flatten the pityriasis.