Marriage and childbirth are a major event in life, and this is also true for patients with rheumatic diseases. Many patients are worried about this issue and are often asked, “Can I still get married? Can I still have children?” “This disease is so serious, it’s a lifetime thing. What should I do?” “Will these drugs affect fertility?” “Will this disease be hereditary?” Such and such questions. For rheumatic immune diseases, we should first pay attention to the fact that this disease is very difficult to cure, at least there are no drugs that can completely cure this type of disease. The main purpose of clinical medication is to control the disease, delay or stop its progress, and avoid serious organ and tissue damage. Therefore, some patients need to take medication for long-term treatment. Of course, during the clinical remission period, the medication can be gradually reduced if the disease is stable, and some patients can even stop taking the medication. This depends on the patient and needs to be judged by the clinician. There may be recurrence in the future, so regular checkups are needed to treat the disease early and prevent it before it occurs. Medication does not affect normal married life, marriage is possible for patients with rheumatism, there is no concern. Just be careful not to overexert yourself, pay attention to physical hygiene and prevent infection. Because infection can easily induce disease recurrence. If you are not planning to have children, you need to pay more attention to using contraception because many anti-rheumatic drugs are harmful to the fetus and an unwanted pregnancy can greatly increase the risk to the fetus. In addition, there can be some effects on the mother. Pregnancy can be an added physical burden for the mother. If you are planning to become pregnant, you need to inform your doctor in advance and they will tell you how to adjust your medication regimen to avoid the effects on the fetus and the mother. In general, the risk of pregnancy is relatively low when the condition is best stabilized for more than six months, and many medications need to be discontinued. Since it takes some time for the medications to clear in the body, they need to be adjusted in advance. Here we talk about those drugs will have an impact. 1, non-steroidal anti-inflammatory drugs: ibuprofen, celecoxib, lexon, etc., these drugs can affect embryonic implantation, resulting in pregnancy failure, generally need to stop a month in advance; 2, biological agents: no clinical studies to confirm, generally require discontinuation of drugs more than 1-3 months; 3, hydroxychloroquine, azathioprine, cyclosporine A: relatively safe, the use of drugs need to be careful, can be considered; 4, hormones: prednisone 15mg or less on Fetal impact is small and relatively safe. 5.Legomorph and cyclophosphamide: due to gonadal suppression, causing infertility, can not be used for a long time if you have fertility requirements. Sulfasalazine affects sperm viability and should be discontinued by men for more than 3 months. Unexpected pregnancy should be examined and evaluated by a doctor to consider whether to terminate the pregnancy. More tests should be performed during pregnancy than normal pregnant women, both fetus and adult should be seen, and joint observation by obstetrician and rheumatologist is required. Also, regarding genetic issues. Numerous studies have shown that children of rheumatic disease patients are more likely to have the same kind of disease than the normal population, but not all children have the same disease occurring. Therefore, patients with rheumatism can marry and have children just like healthy people. They can also have their own happy families and healthy babies.