The typical lesion of dermatomyositis, an edematous purplish-red patch on both upper eyelids, spreads to the periorbital area and gradually expands to the V-zone of the face, neck and upper chest. A purplish papule on the extremities of the elbows and knees, especially on the extensor side of the metacarpophalangeal and interphalangeal joints, with dilated capillaries and hypopigmentation, covered with fine scales, is called Gottron’s (Gordon) sign or Grottron’s papule. It is associated with a variety of infections. So, what tests should be done in patients with edematous purplish spots on both upper eyelids? The following is a brief description: 1. Serum sarcoplasmic enzyme measurement: serum creatine phosphokinase (CPK), aldolase, (AST), alanine aminotransferase (ALT), lactate dehydrogenase measurement value increased, especially CPK, serum enzyme increase is often parallel to the disease muscle lesions, can reflect the activity of the disease, generally in muscle strength before the improvement of 3 to 4 weeks, 5 to 6 weeks before the clinical relapse increased It can predict the deterioration of the disease. 2.Immunological test: two types of autoantibodies can be detected in the serum of DM/PM patients. 3.Increased urinary creatine excretion: The synthesis process of creatine in normal condition is firstly, the transfer of amidine group from arginine to glycine to become guanidinoacetic acid, and secondly, guanidinoacetic acid accepts methionine methyl group to become creatine, which is synthesized in liver, mostly taken up by muscle, and exists in the form of phosphocreatine containing high-energy phosphate bond, in which high-energy phosphate bond can be transferred to adenosine diphosphate under the catalysis of phosphocreatine kinase to generate adenosine triphosphate When the synthesis of adenosine triphosphate increases, part of the phosphate can be stored in creatine phosphate through the reverse reaction. 4, histological changes: muscle is widely or partially invaded, muscle fibers are initially swollen, transverse lines disappear, sarcoplasmic hyalinization, myofibrillar nuclei increase, muscle fiber separation and fracture.