Cancer, it seems natural to need radiotherapy, chemotherapy, and sometimes high-dose interferon and interleukin therapy. Many patients are well aware of the toxicity of radiotherapy and chemotherapy. Yes, the issue of toxicity makes the patient’s choice a tangled one. In fact, for cancer patients, it is not only the toxic side effects that need to be torn, but also, more importantly, special beware: radiotherapy, chemotherapy, high-dose interferon, interleukin therapy, do these treatments, have any effect on the tumor? What kind of effect do they have? Don’t tolerate the toxicity and not get the benefit. Therefore, several issues need to be pointed out, and we hope you will understand: 1. For most advanced cancers, the effect of chemotherapy is actually not ideal. For chemotherapy, we used to value whether it can control the tumor. When surgery cannot be removed and there is no better option, most chemotherapy can only achieve 20-30% of the effect. In other words, only a small percentage of patients can have their tumors partially shrink. Even if the tumor shrinks, it will not be maintained for a long time. Generally, after 3-6 months, the tumor will continue to grow. 2. Although the tumor shrinks in the short term, the survival time is not necessarily extended. The purpose of radiotherapy and chemotherapy is to kill the cancer, but the cancer is often killed but not destroyed. Therefore, only by increasing the dose of radiotherapy and chemotherapy, increasing the dose of interferon and interleukin, the tumor may shrink, but the toxicity also increases, the patient’s quality of life is reduced, and the survival time is sometimes shortened. And it is now accepted that high quality of survival and long survival time are the most important efficacy. The examination of survival time, such as 1 year, 3 years, or 5 years, is obviously difficult to evaluate with only a small amount of experience of individual doctors. That is why international emphasis is placed on evidence-based medicine, and there are a large number of clinical trials conducted by medical doctors all over the world to compare various cancers and various treatments, analyze the efficacy, and then recommend the best option. Therefore, oncologists generally respect international guidelines (NCCN guidelines). Cancer patients, prior to treatment, can also therefore anticipate the benefits that will result from the treatment regimen, especially in terms of survival time. If the treating doctor cannot tell you this, it means he is dizzy, does not understand the guidelines, or pretending to be confused. 3, radiotherapy and chemotherapy, not all patients need it, the key depends on whether the patient can benefit from it. Generally speaking, radiotherapy is mainly used to control local cancer, or for removing residue after surgery. Radiotherapy is only good for local control, but the effect of controlling metastasis is relatively small. In many cases, radiotherapy does not extend survival time. For example, after surgery for malignant melanoma, if radiotherapy is used, although it will slightly reduce local recurrence, the patient’s survival time cannot benefit. Chemotherapy is mainly used for advanced cancer, or when the risk of recurrence is high after surgery. Chemotherapy is not always needed after surgery, and should not be used lightly if the cancer is early staged and little or no chemotherapy is needed, or when the tumor is not sensitive to chemotherapy. As an example, for stage I-II colon cancer, if chemotherapy is administered after surgery, the patient’s survival benefit will not exceed 5%, so chemotherapy should not be recommended. There is also interferon. After kidney cancer surgery, some hospitals give high-dose interferon to patients. However, in fact, after kidney cancer surgery, neither the use of interferon nor chemotherapy can reduce cancer recurrence nor prolong survival time. These, in the NCCN guidelines are clearly written, but there are doctors who still use it, and patients are unaware of it and take it for granted. The reason why I am writing about the above issues today is because some patients have been inquiring about it recently. And we do find that there are patients who are not getting the best treatment in Western hospitals, or even getting excessive and unnecessary treatment.