There are special suppositories for chronic proctitis, for example, Mesalazine suppository is one of them. Mesalazine suppositories are suppositories and topical medications that are indicated for the treatment of inflammatory bowel disease, especially ulcerative colitis, Crohn’s disease, and ulcerative colitis. When applying mesalazine suppositories, it is necessary to perform a bowel movement, followed by inserting the suppository through the anus. The main effect of treatment with mesalazine suppositories is the direct contact of the drug with the intestinal mucosal lesions, the release of the drug in the distal part of the intestinal tract, and relatively little systemic absorption. Adverse effects of mesalazine suppositories mainly include nausea, diarrhea, allergy, and abdominal discomfort, etc. It is contraindicated for those who are allergic to mesalazine suppositories. If there is any discomfort, seek medical attention, the application of mesalazine suppositories has certain risks, it is recommended that patients under the guidance of a doctor.