Rheumatoid arthritis (RA) is a systemic, autoimmune disease with symmetric polyarthritis as the main clinical manifestation. Most patients have a progressive exacerbation process, which can lead to joint deformities if not treated appropriately and progressively. Therefore, early diagnosis and treatment are essential. This disease is one of the leading causes of labor loss and disability in humans. If you notice swelling and pain in the small joints of your hands, accompanied by stiffness in your hands when you wake up in the morning, you need to be alert to the possibility of the disease. Ancillary tests such as rheumatoid factor, anti-cyclic citrullinated peptide antibodies, C-reactive protein, and X-rays of both hands are needed at this time to clarify the diagnosis. However, in 20-30% of patients, especially those over 60 years old, rheumatoid factor and anti-cyclic citrullinated peptide antibodies may be normal, and other tests are needed at this time to clarify whether the disease is rheumatoid arthritis.