The condition of panic and shaking after taking antidepressants is usually caused by the side effects of the medication, so it is recommended that patients follow the guidance of a professional doctor when taking the medication and do not take it blindly. If the patient’s discomfort is obvious, it is recommended to go to the hospital and follow the doctor’s instructions for appropriate treatment. Antidepressants include traditional antidepressants and new antidepressants, which are mainly used to treat various anxiety disorders or depression disorders. Traditional antidepressants include Maprotiline hydrochloride, Amitriptyline hydrochloride, etc., while new antidepressants include Paroxetine hydrochloride, Duloxetine hydrochloride, etc. The main mechanism of action of antidepressant drugs is to improve depression by increasing the content of central neurotransmitters related to mood in certain areas of the brain, such as pentraxin or norepinephrine. At the same time, antidepressant drugs have sympathomimetic hyperactivity, if the patient is sensitive to the components of antidepressant drugs or the dose of drugs taken is high, when the body sympathetic excitement, norepinephrine secretion increases, the peripheral effect can be manifested as a rapid heartbeat, the patient will feel panic, palpitations, but also muscle tremors, the patient’s limbs shaking and other symptoms. Therefore, patients are advised to take the medication on time, according to the dose and the course of treatment as prescribed by the doctor. When the above symptoms appear, if the symptoms are mild, patients can continue to take the medication to avoid affecting the treatment of the disease; if the symptoms are more obvious, patients are advised to seek medical advice in time to identify the cause of the disease and then carry out symptomatic treatment. In addition, it is recommended that patients pay attention to the regularity of work and rest during the medication period, maintain sufficient sleep, and avoid overexertion, so as to help the recovery of the disease.