Conventional treatment of SLE includes the use of hormones, immunosuppressants, etc. Although effective, in most cases, it merely controls disease activity. And it often requires lifelong medication. The new treatment approach, which we will tentatively call sequential therapy. As projected, this approach should result in reduced hormone dosage, no or less use of immunosuppressants such as cyclophosphamide, azathioprine, leflunomide, primidone, etc., and even discontinuation of drug therapy in patients in remission. The therapy should have fewer side effects than immunosuppressive drugs. The new approach has shown its good results and exceeded expectations. A patient whose disease activity could not be controlled with 80 mg of methylprednisolone was rapidly controlled with sequential therapy with 40 mg of hormone and the facial erythema disappeared. In another case of severe lupus pneumonia, the disease was rapidly controlled by sequential therapy with 40 mg of hormone, and in several cases of lupus nephritis, the blood complement increased and urine protein decreased after using this method. However, only about 10 cases of this therapy have been applied, and more cases are needed to confirm its efficacy and side effects. As with conventional treatments, this therapy may not prevent lupus from recurring.