Many patients in the clinic are afraid of the closed therapy mentioned by doctors. Of course, I can not know the reason for this fear, the general patient always think that doctors use closed therapy is to temporarily let him or her feel no pain, after the effect of the drug will still produce pain, think this is a cure for the symptoms of the method and not willing to accept. In order to let more people understand this method, the following is a brief description of the specific clinical operation of this method: 1, the drugs used in closed therapy: closed therapy commonly used drugs including local anesthetics, steroidal anti-inflammatory drugs, neurotrophic drugs. Local anesthetics are often used lidocaine and bupivacaine, the main difference between the two drugs is their duration of action, although the cardiotoxicity of bupivacaine, but the dose used in closed therapy is usually within the safe dose. The most important way to avoid toxicity of local anesthetics is for the physician to keep pumping back during the injection operation to avoid intravascular injection. Steroidal anti-inflammatory drugs are what we usually call hormonal drugs. The hormonal diseases used in closure are long-acting hormones, such as trimethoprim, compound betamethasone and dexamethasone, which are commonly used in clinical practice, and their main role is to inhibit the production of pain-causing inflammatory factors and interrupt the vicious cycle of pain. Neurotrophic drugs are usually only used in diseases with neurological dysfunction. 2, closed therapy application precautions: patients are most concerned about the steroids in closed therapy, in fact, as long as the patient does not have a history of severe hypertension, severe diabetes and peptic ulcers can generally be used safely. For patients with the above-mentioned diseases, if the condition requires the application can also be under the guidance of a doctor, such as increasing the anti-hypertensive drugs. The amount of hypoglycemic drugs and the use of gastric mucosal protective agents and other measures under the safe use, of course, the use of ozone replacement therapy is also feasible. 3, the course of closed therapy: closed therapy is usually once a week, generally 3-5 courses of treatment. Many patients in the closed therapy produced a certain efficacy after the fear of side effects and did not adhere to the treatment is not correct.