What are the treatment options for lymphoma? The current treatment for lymphoma is mostly in the form of comprehensive treatment. Your doctor may choose an appropriate treatment plan for you based on the type of tumor and overall condition, including chemotherapy, radiotherapy, bone marrow or hematopoietic stem cell transplantation, surgical treatment, and biological treatment. Liu Li, Department of Hematology, Tangdu Hospital, Fourth Military Medical University Comprehensive treatment is better than single treatment because each means of treatment works differently, some work this way and some work that way. It is just like fighting a war, we need to fight with multiple types of soldiers, artillery has the role of artillery, rifle has the use of rifle, and joint cooperation can play a greater benefit. The same is true for tumor warfare. Integrated treatment can maximize the destruction of lymphoma cells. What are other treatment methods for lymphoma? I. Bone marrow or hematopoietic stem cell transplantation Hematopoietic stem cell transplantation is to pre-treat lymphoma patients with intense radiotherapy and chemotherapy to kill the cancer cells in the patient’s body to the maximum extent, and then to implant hematopoietic stem cells into the body to restore their hematopoietic and immune functions. The currently available hematopoietic stem cells are mainly derived from bone marrow, peripheral blood or fetal umbilical cord blood from autologous or allogeneic (siblings or unrelated donors who meet the matching requirements) sources. In the treatment of lymphoma, autologous peripheral blood hematopoietic stem cell transplantation, or autologous bone marrow transplantation is most commonly used, and a few patients may be considered for treatment with allogeneic hematopoietic stem cell transplantation. Stem cell transplantation is a means of treating lymphoma, but not all patients will be successful, and about 30% will fail in treatment. The main reasons for failure are advanced stage, tumor relapse and drug resistance, high tumor load before transplantation or high malignancy. After stem cell transplantation, there is still a certain chance of recurrence and other treatment-related risks. Therefore, it is necessary for doctors to communicate well with patients, consider carefully, and choose effective treatment timing. Surgery If hypersplenism is indicated, splenectomy can be performed to improve blood picture and create favorable conditions for future chemotherapy. Biological treatment of lymphoma Currently, the medical community believes that there are three types of drugs available for biological treatment of lymphoma: Monoclonal antibody: CD20 positive B-cell lymphoma can be treated with CD20 monoclonal antibody Meroval® (rituximab). Moreover, B-cell lymphoma can greatly improve the efficacy of transplantation treatment by using Merova® (rituximab) to do in vivo tumor cell decontamination prior to hematopoietic stem cell transplantation. Meroval® (rituximab) is the world’s first monoclonal antibody approved for the clinical treatment of non-Hodgkin’s lymphoma (NHL). Interferon: Partial remission in mycosis fungoides and follicular schwannoma type lymphoma. Anti-H. pylori drugs: lymphomas in the marginal bands of mucosa-associated lymphoid tissue outside the gastric nodes can be improved and the lymphomas disappear in some patients after anti-H. pylori treatment.