Deep subfascial lipomas of the thigh may not require treatment if they are asymptomatic or slow-growing. If the growth is accelerated and there is pressure on the surrounding tissues, it can be treated by surgical excision. Lipoma is a common soft tissue benign tumor composed of mature fat cells. It can occur in any fatty area, and those under the deep fascia of the thigh are called deep lipomas. It is mostly seen in middle-aged people aged 40-60 years old, mostly grows along the muscle, and can reach deep to the periosteum. Isolated lipoma within 1cm in diameter, or small and without obvious pain, not affecting aesthetics, can be treated conservatively by actively controlling the diet, moderately increasing the amount of exercise, and paying attention to the review can be. If the lipoma is large or has obvious pain and other symptoms, or affects the aesthetics of the patient’s strong desire for treatment, it can be surgically removed. Deep fascial lipomas are sometimes difficult to remove completely and may recur, but basically will not become malignant. Lipoma excision is usually a minor surgery, but also need to go to the hospital standardized medical treatment, according to the surgical process to ensure safety.