The pathology of chronic atrophic gastritis is characterized by atrophy to reduction or disappearance of the intrinsic glands of the gastric mucosa, which is closely related to the occurrence of gastric cancer and often develops precancerous lesions such as intestinal epithelial hyperplasia on the basis of glandular atrophy, which then evolves into gastric cancer. When there is already obvious atrophy formation, it is difficult for drugs to play an obvious role, so the timing of treatment is especially important. The main treatment modalities are: 1. Eradication of H. pylori. As early as 1994, the WHO identified H. pylori (Hp) as a class I carcinogen for gastric carcinogenesis, and there is an international consensus that eradication of Hp is important for the prevention and treatment of carcinogenesis in chronic atrophic gastritis. the second edition of the NCCN guidelines 2009 China specifically mentions the treatment of Hp: if the test is positive, treatment is needed. The eradication of Hp has been reported to contribute to the improvement of atrophic gastritis. 2. Enhance the defense function of gastric mucosa. The pathological formation of chronic atrophic gastritis is mainly caused by long-term inflammatory stimulation causing the destruction of multiple glandular structures, so enhancing the defense and repair of the gastric mucosa is the key to treatment. The main mechanism is to prevent gastric acid and pepsin from destroying the mucosal barrier by adhering to the gastric mucosa, promoting prostaglandin synthesis and epidermal growth factor secretion. 3, supplementation of antioxidants. It has been found that long-term supplementation with antioxidant vitamins (vitamin C and vitamin E), folic acid and beta carotene has a role in preventing and blocking chronic atrophic gastritis. The combined application of Hp eradication and antioxidants is now widely favored. 4, Chinese medicine treatment. The main choice is to protect the gastric mucosa, anti-inflammatory and antibacterial, astringent and hemostatic, promote healing, reduce swelling and stasis, open the stomach and relieve pain, improve the blood circulation and metabolism of the atrophic glands, in order to restore the acidic environment in the stomach.