Frequent abdominal pain may be a symptom of cancer, but not all abdominal pain is cancer. Abdominal pain may be associated with a variety of conditions within the abdomen or abdominal region. Abdominal pain can occur in cancerous diseases and is a relatively common symptom in the developmental changes of many cancers or other diseases. Abdominal pain can occur in cancer due to direct nerve irritation caused by the erosion of abdominal organs by cancerous tissue, or painful discomfort caused by nerve compression caused by cancerous tissue as it increases in size or causes obstruction of hollow organs in the abdomen. However, many other abdominal specific and non-specific inflammatory diseases can cause abdominal pain, especially some long-standing diseases that can cause frequent abdominal pain, such as intestinal tuberculosis, chronic gastritis, gastric ulcer, and chronic enteritis, which are all non-cancerous causes of abdominal pain. Anatomically speaking, the abdomen is composed of organs up to the diaphragm and down to the pelvis. Diseases caused by these organs may cause various kinds of abdominal pain of different severity and nature. These organs are numerous, and it is not cancerous diseases that cause abdominal pain; some ordinary physical, chemical, and biological stimuli can cause abdominal pain to occur. Cancer is a disease with a high metabolic rate and an aggressive, metastatic and spreadable capacity. Cancerous diseases that cause abdominal pain may lead to some manifestations of poor nutritional status, bleeding, and spread. Diagnosis of cancer requires great care and should not be made solely on the basis of frequent abdominal pain.