Impotence and premature ejaculation are two different diseases and use different treatment drugs. Impotence patients can use phosphodiesterase inhibitors, androgens to treat; premature ejaculation can be oral dapoxetine, paroxetine and other drugs, but also external lidocaine cream and other drugs. 1. Impotence: (1) phosphodiesterase inhibitors: this type of drug has sildenafil, tadalafil, vardenafil, etc., is the first choice of drugs for the treatment of impotence, the use of such drugs need to be under the guidance of a doctor, this type of drug is not applicable to all patients, and some patients will have a headache, indigestion and other symptoms after taking the drug. (2) Androgens: These drugs are used to treat impotence caused by low androgen levels, such as testosterone undecanoate pills, which can increase the patient’s libido. 2. Premature ejaculation: patients can take oral 5-hydroxytryptamine reabsorption inhibitors (dapoxetine, paroxetine, sertraline), tricyclic antidepressants (chlorpromazine) under the guidance of a doctor, after taking the drug, some patients will appear nausea, dry mouth, diarrhea, loss of libido and other symptoms. Local anesthetics such as topical lidocaine cream can also be used to reduce the sensitivity of the penis head and control ejaculation. The use of the above drugs must follow the doctor’s instructions, not unauthorized use of drugs or listen to prescriptions indiscriminate treatment, resulting in adverse consequences.