Hypertension after the change of medication blood pressure rise is mostly considered to be the original antihypertensive drug discontinued, the role of the new drug has not yet taken effect caused by, may also be insensitive to the role of the new drug, or change of medication caused by the mental tension, or sleep deprivation, dietary reasons, etc., need to be based on the patient’s specific situation, to take a different approach to deal with. If patients with hypertension have good blood pressure control after taking medication, and there is no special adverse reaction, it is generally not recommended to change medication frequently, and if you need to change medication, you should pay attention to the following points: 1. When changing medication, the old medication should be overlapped with the new medication for 2~3 days, so that the effect of the new medication can be brought into full play and the blood pressure will not be elevated. 2. When you are not sensitive to the effect of the newly changed antihypertensive drug, you can take two or more antihypertensive drugs. 3. Patients with high blood pressure need to have a low-salt and low-fat diet, get enough sleep, maintain emotional stability and avoid mental stress. 4. For patients with high blood pressure, they need to be hospitalized for observation, adjust medication under doctor’s guidance, and be discharged from the hospital when their blood pressure stabilizes, and then take medication regularly to make their blood pressure reach the standard, and have regular checkups. If the blood pressure is not well controlled, it is recommended to consult a doctor in time.