The white soles of the feet with small honeycomb holes may be a symptom of plantar warts, fossa keratolytica or tinea pedis, and it is important to go to the dermatology department of the hospital to make a clear diagnosis in a timely manner. Treatment options include physical therapy, antiviral therapy, antibacterial therapy or antifungal therapy. 1. Plantar warts are caused by viral infection, manifesting as scattered or dense white depressions or flat bumps on the soles of the feet, with rough surface and black spots. Plantar warts can be treated with physical therapy such as laser or electrocautery, or antiviral drugs such as topical interferon spray and imiquimod cream. 2. Vulval keratolysis is caused by bacterial infection and is most common in people with chronically wet feet, such as migrant workers. It manifests as whitish skin maceration on the feet with honeycomb-like skin depressions on the surface. Treatment can be topical fusidic acid cream, erythromycin ointment and other antiseptic ointment. 3. Tinea pedis is caused by fungal infection, manifested as dense blisters on the soles of the feet or toe crevices, blisters dry up or tear off the epidermis after a dense honeycomb-shaped vesicle surface, accompanied by intense itching. It can be treated with topical ketoconazole cream, terbinafine hydrochloride cream and other drugs. The soles of the feet white with honeycomb holes can also be seen in pitting palmoplantar keratosis, etc., the use of drugs before consulting a doctor, under the guidance of the doctor to use.