Renal insufficiency is generally allowed to take melatonin, but it should be taken under the guidance of a physician, not without authorization. Melatonin is a hormone secreted by the pineal gland for its ability to regulate the circadian rhythm. It can be used clinically to treat patients with insomnia, and can also make patients fall asleep faster. Melatonin is relatively safer, but it is not recommended for pregnant and lactating women or children. Elderly patients also need to use it with caution. For patients with renal insufficiency, it can be used appropriately, but need to follow the doctor’s advice. In the process of using melatonin, if dizziness, headache, drowsiness and other discomforts occur, it is recommended to stop using it promptly. Patients with renal insufficiency must follow the doctor’s instructions when taking melatonin, and cannot use it on their own, so as not to react with other therapeutic drugs and affect the therapeutic effect.