Chromosome split abnormality may be related to physical factors, biological factors, chemical factors, genetic factors and so on. 1. Physical factors: The radiation environment in which human beings live, including natural and artificial radiation, may lead to abnormal chromosome division if they are exposed to radiation for a long period of time, or when they are exposed to X-rays. 2. Biological factors: When viruses are used to treat cells in culture, such as cytomegalovirus and measles virus, they may lead to many types of chromosome aberrations, including breakage, crushing and interchanging. 3. Chemical factors: People are exposed to a variety of chemicals in their daily lives, such as chemical drugs, pesticides, benzene, toluene, etc., which may lead to an increase in chromosomal aberrations and abnormal chromosome splitting. 4. Genetic factors: If there are chromosomal abnormalities in both parents, they may be passed on to the offspring in the process of reproduction through mitosis, meiosis and the formation of fertilized eggs, causing abnormal chromosome division. In the event of chromosome abnormality, you should go to the hospital immediately to complete the relevant examinations, and the doctor will give appropriate treatment and therapy according to the results of the examination.