The management of gastrointestinal neurosis can start from the mental aspect such as strengthening exercise, relaxing mood and medication such as anti-anxiety drugs and acid-suppressing drugs. Gastrointestinal neurosis is mostly caused by mental tension and secondary to a series of digestive diseases such as gastritis and peptic ulcer. Therefore, the treatment can start from improving the mental condition and correcting the digestive tract diseases. Patients can strengthen exercise, relax, participate in social activities and communicate with others to improve the mental condition of anxiety and nervousness. If necessary, anti-anxiety drugs such as diazepam can be given to play the effect of anti-anxiety, sedation, sleep and so on. For digestive tract diseases, mostly due to increased gastric acid secretion, can be given to acid-suppressing drugs, such as omeprazole, ranitidine, the medication should follow the doctor’s instructions.