Antihypertensive drugs and lipoic acid and aspirin can be applied at the same time, but need to be under the guidance of a specialized physician. Antihypertensive drugs refer to the drugs that can control the changes of blood pressure and have the effect of lowering blood pressure, and the representative drugs are nifedipine extended-release tablets, enalapril, metoprolol, furosemide, and valsartan. Lipoic acid is a kind of protein with the effect of blocking protein glycosylation, can be used to treat diabetes mellitus multiple peripheral neuropathy. Aspirin has an inhibitory effect on platelet aggregation and is commonly used for secondary prevention in patients with stroke and myocardial infarction. The mechanism of action of the three drugs are different, do not interfere with each other, patients with a variety of chronic diseases, due to the need for the condition, the three drugs can be used together. Improper application of antihypertensive drugs can lead to low blood pressure, and common nausea, edema, palpitations and other adverse reactions, allergy to the drug is prohibited. Lipoic acid may cause nausea, vomiting, abdominal pain, diarrhea, skin rash, taste changes and other adverse reactions, but it is rare, allergic to the drug is prohibited. Improper application of aspirin can lead to gastrointestinal bleeding, allergic to the drug, severe peptic ulcer, bleeding disorder is prohibited. The use of the above drugs need to be under the guidance of a professional physician, not blindly use their own medication, so as not to lead to adverse consequences.