There are physiologic and pathologic causes for the small transparent bubbles in the nail shell, and the pathologic causes include viral infection and fungal infection, which can be treated with antiviral drugs and antifungal drugs. 1. Physiological causes: transparent bubbles in the nail shell may be improper nail bed, in the process of nail growth, there may be some stripping with the nail bed, resulting in transparent bubbles in the nail shell, with the growth of the nail will slowly subside, do not need too much intervention. 2. Pathologic causes: (1) Viral infection: due to the tiny trauma of the local skin infected with viruses, resulting in the appearance of small transparent bubbles in the shell of the fingernail, can be treated with antiviral drugs such as acyclovir cream, acyclovir tablets, vasiclovir tablets, and other antiviral drugs. (2) Fungal infection: Fungal infection leads to onychomycosis and the appearance of clear vesicles in the nail shells, which can be treated by topical application of amorolfine hydrochloride or oral intake of antifungal drugs such as terbinafine hydrochloride tablets. If there are transparent vesicles in the fingernail shell, it is recommended to go to the hospital in time to identify the cause of the disease and then carry out targeted treatment to avoid adverse consequences. Drugs should be used under the guidance of a doctor.