The specific causes of SLE are not yet completely clear, and may be related to environmental, genetic, endocrine and other factors. 1. Environment: Environmental factors mainly include drugs, sunlight and pathogenic microbial infections. Ultraviolet rays from sunlight directly shining on the skin may lead to the production of autoantibodies, thus aggravating or triggering the disease; Phenytoin sodium, quinidine and isoniazid may lead to a decrease in the degree of DNA methylation and cause the disease; microbial infections such as microbial viruses, cytomegalovirus and other microbial infections may also trigger the disease. 2. Heredity: SLE patients have a family history of other patients diagnosed with the disease, so a genetic link is considered. 3. Endocrine: SLE is most common in women of childbearing age, so it may be related to estrogen secretion in women. The occurrence of SLE may also be related to other factors. It is recommended that SLE patients should go to the rheumatology and immunology departments of regular hospitals for detailed consultation, so as to clarify the cause of the disease and follow the doctor’s instructions for standardized treatment.