A clean margin of excision for colonic adenomas is often seen in the description of the pathologic histologic examination after adenoma resection, indicating that the mass was removed intact. Because colonic adenomas are more likely to be cancerous, treatment should include early surgical resection, with emphasis on complete removal of the mass to avoid malignant transformation of the leftover tumor tissue. The resected pathological tissues should be sent for examination after surgery, and the abdomen can be closed only after the professional physician’s examination suggests that the margins are complete and clean. Colonic adenomas are often initially altered as colonic adenomatous polyps, and about 70% of colon cancers are evolved from adenomatous polyps, and the stages of hyperplasia, adenoma and carcinoma as well as corresponding chromosomal alterations can be seen from the morphology, which takes 10-15 years, but there are some cancers that do not evolve from adenomas and appear directly in the form of cancer nests. Colonic adenoma is still a benign lesion, the mass often has a peripheral membrane, smooth surface, clear boundaries with the surrounding, and generally no metastasis. If colon adenoma is found, one should go to the hospital in time for treatment, and after resection, one should follow the doctor’s instructions for regular review.