Monkeypox is a zoonotic infectious disease, monkeypox virus can be transmitted through direct transmission between humans and animals, and indirect transmission between humans and humans infected with the disease. 1. Direct transmission between humans and animals: when the disease is first transmitted between humans and animals, humans can be infected with monkeypox virus through contact with the blood, body fluids or excreta of infected animals, or infected with the disease through being bitten by animals with monkeypox virus in their bodies. 2. Indirect transmission: monkeypox virus can also be transmitted during long-term face-to-face contact between human beings, through respiratory tract discharges such as sputum, saliva, droplets, etc. In addition, it can also be transmitted through broken skin surface, body fluids, excretions or virus-contaminated articles such as clothing and bedding, etc. Therefore, monkeypox virus can be transmitted through blood, body fluids or excretions. Therefore, monkeypox virus can be transmitted through blood, droplets and body fluids between animals and humans, and between humans. It is recommended to stay away from high-risk areas and avoid contact with infected people.