Azelaic acid and adapalene gel are topical skin medications that can be used for the treatment of acne vulgaris. The two medications can be used together for the treatment of acne if necessary, but they should be used at certain intervals or separately in the morning and in the evening, and are not recommended to be used together. Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus ostreatus, which works by inhibiting microbial protein synthesis, thereby relieving acne symptoms. Adapalene Gel is a retinoid compound, can play a certain anti-inflammatory effect, for acne symptoms, can play a role in dissolving microcomedones, preventing the blockage of follicular opening, to further reduce and improve the symptoms of acne. For patients with facial acne, they should cooperate with the doctor to give medication, and azelaic acid and adapalene gel are both commonly used drugs. If necessary, they can be used together as prescribed by the doctor, but due to the presence of some irritation and the photosensitizing properties of retinoids, they are usually used at certain intervals or separately in the morning and evening. It is important to note that although these two drugs can be used together, but should strictly follow the doctor’s instructions to use the drug, patients who are allergic to some components of adapalene or azelaic acid should be prohibited from using.