Babies may have local and systemic reactions after receiving the 13-valent vaccine. 1. Local reaction: Redness, swelling, pain, itching, hardness and other local symptoms may appear at the site of 13-valent vaccine injection, and the vaccine liquid may also stimulate the surrounding muscles, causing muscle pain at the site of vaccination. 2. Systemic reaction: 13-valent vaccination will stimulate the body’s immune response to the vaccine immune response of the baby can appear fever; some babies are allergic to the vaccine will also appear generalized rash, itching, nausea, vomiting, diarrhea, irritability, difficulty sleeping, decreased appetite and other systemic reactions. It should be noted that not all babies will have adverse reactions after vaccination. Babies need to be vaccinated on time, if your baby is not adapted to the 13-valent vaccine, go to the hospital in time, under the guidance of the doctor, timely and standardized treatment, to avoid further aggravation of the condition.