Patients with thyroid nodules are usually able to receive the HPV vaccine when their condition is stable. If severe symptoms occur, it is recommended to receive the vaccine after their condition has been controlled and stabilized. Thyroid nodules are abnormal proliferation of thyroid cells, resulting in nodular masses in the thyroid tissue.HPV vaccine, also known as human papillomavirus vaccine, is indicated for women of the appropriate age group to be vaccinated against human papillomavirus infection. Clinical symptoms in patients with thyroid nodules include pain around the nodules, but having thyroid nodules does not affect HPV vaccination. As long as the condition is under stable control and there are no other complications, it is possible to receive the vaccination as scheduled. If there are other complications, such as hyperthyroidism, and the patient is in the acute phase, it is recommended that the patient’s condition be stabilized before vaccination.