A cauliflower-like growth on the male foreskin may be related to condyloma acuminatum and penile cancer. 1. Condyloma acuminatum is mostly due to human papilloma virus infection, mostly occurring in the coronal groove, the prepuce and around the anus, the first time is a small reddish pimple, and slowly formed a cauliflower-shaped protuberance, and often occurs vesiculation, oozing. 2. Penile cancer is a malignant tumor originated from the mucous membrane of the head of penis, coronal groove and inner plate of prepuce as well as the skin of penis. It is the most common malignant tumor of penis, accounting for more than 90% of penile tumors. The lesions appear as papules, papillae or flat protuberances, warts or cauliflower-like plaques, ulcers, and the lesions gradually increase in size, often accompanied by foul-smelling discharge on the surface. The male foreskin grows a cauliflower-like can also be seen in other causes, it is recommended to timely medical treatment, comply with the doctor’s instructions for the relevant examination, in the doctor’s help treatment.