Lateral ankle pain may be caused by fatigue injury, cold and other factors, or it may be caused by trauma, degeneration of the ankle joint and other pathologic factors. 1. Physiological factors: the lateral side of the ankle is clinically known as the outer ankle, and there are many tendons, ligaments and other soft tissues running through the outer ankle area. Long-term walking or standing for a long time or sitting for a long time will lead to fatigue of the soft tissues of the outer ankle area, which will lead to lateral ankle pain; those who like to expose the neck of their feet may cause long-term coldness of the outer ankle area, which will also lead to the above mentioned symptoms. 2. Pathological factors: trauma to the ankle area may lead to ligament tear, ankle fracture and other conditions, resulting in local soft tissue congestion and edema as well as destruction of the joint structure, which may also lead to lateral ankle pain; degenerative diseases of the ankle joint may lead to intra-articular osteophytes, increased impact in the joint, which may also lead to the above symptoms. There may also be other causes of lateral ankle pain, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.