Stomach discomfort after drinking cold water may firstly be caused by the irritation of cold water, which needs no treatment. Secondly, it may also be caused by gastritis, gastric ulcer, etc., which needs to be treated with medication and surgery according to the cause. 1. Cold water stimulation: generally after drinking cold water may produce stimulation of the gastric mucosa, which will cause spasmodic contraction of the smooth muscle of the stomach, the patient may have stomach pain and other stomach discomfort. This is a normal phenomenon, can not take measures to treat. Most patients apply hot compresses to the abdomen, which can relieve the smooth muscle tension in the stomach. 2. Gastritis: Patients with gastritis may also feel stomach discomfort after drinking cold water. Patients can use proton pump inhibitors such as omeprazole and pantoprazole, as well as H2 receptor antagonists such as cimetidine and ranitidine under the guidance of a doctor. In addition, for localized high-level epithelial sarcomatoid lesions that cannot be reversed by drugs, it is necessary to take submucosal stripping treatment under gastroscopy. 3. Gastric ulcer: patients who feel stomach discomfort after drinking cold water need to use gastric mucosal protective agents such as magnesium aluminum carbonate and aluminum thioglycollate under the guidance of doctors. For patients with Helicobacter pylori infection, it is necessary to take quadruple therapy treatment as prescribed by the doctor, and commonly used drugs include amoxicillin, metronidazole, lansoprazole, bismuth potassium citrate and so on. If gastric ulcer patients have repeated bleeding or the lesion is suspected to be malignant, they need to take surgery to remove the ulcer site. Patients drinking cold water after stomach discomfort may also be indigestion, gastric cancer and other causes, it is recommended that patients exclude physiological factors caused by stomach discomfort, the need to consult a doctor in a timely manner, and comply with the doctor’s instructions for treatment.