Fetal chromosomal abnormalities need to be categorized into types of abnormalities, some of which can cause serious adverse consequences and require a decision by both spouses as to whether or not the pregnancy should continue. Fetal chromosomal abnormalities are mainly caused by advanced maternal age, genetics, and exposure to teratogenic factors. Some fetal chromosomal abnormalities may cause serious adverse outcomes, such as trisomy 21, trisomy 13, or trisomy 18 in which the fetus has not only chromosomal abnormalities, but also often multiple structural problems. Among them, trisomy 21 can affect significant intellectual developmental impairment, short stature, reproductive ability, etc., and even inability to take care of themselves, causing a certain burden on the family. While some chromosomal abnormalities basically do not affect later in life, as with normal people, and does not affect their life expectancy, couples then conduct professional genetic counseling to decide whether they need to continue the pregnancy. When the fetus is diagnosed with chromosomal abnormalities, the couple should decide whether to continue the pregnancy according to the actual situation. It is also recommended that the next pregnancy should be preceded by prenatal diagnosis to check for chromosomal conditions.