Ineffective timosartan tablets can be replaced with valsartan, but it is recommended that the change of medication be done under the supervision of a doctor. Timosartan and valsartan are both angiotensin II receptor antagonists, and timosartan is mainly used for the treatment of essential hypertension and cardiovascular risk reduction in adults. Valsartan is mainly used for the treatment of mild to moderate essential hypertension, and both have approximately the same utility and can be replaced. However, it should be noted that valsartan can cause adverse reactions such as hepatic and renal impairment, vasculitis, angioedema, rash, itching, etc. If overdosed, it can cause significant hypotension, which can lead to decreased consciousness, circulatory failure or shock, so it is recommended to carry out the process of medication substitution under the guidance of a doctor.