The causes of gastric wall thickening may be gastritis, gastric smooth muscle tumor, gastric cancer, etc., and the hazards vary with different causes. The common ones are abdominal pain, nausea and vomiting, upper gastrointestinal bleeding, difficulty in swallowing, etc., and the serious ones will affect the life span. 1. Gastritis: Gastritis will lead to congestion and swelling of the mucosa of the stomach, which is manifested as thickening of the stomach wall in CT examination. Usually there will be epigastric discomfort, nausea and vomiting, belching and other manifestations, and in serious cases, further development may lead to ulcers, bleeding and so on. 2. Gastric smooth muscle tumor: Gastric smooth muscle tumor will cause local thickening of the stomach wall, which usually does not produce obvious symptoms. If it increases to a certain extent, it may cause obstruction of the digestive tract and rupture of local blood vessels. 3. Gastric cancer: gastric cancer is a great threat to patients’ health, and most of the patients do not have symptoms in the early stage, so it is highly hidden. With the development of the disease, there is usually pain in the upper abdomen and a lump can be touched. When the disease enters the advanced stage, weight loss will be obvious, and at the same time, distal metastasis will occur and a series of systemic symptoms will appear. To summarize, whether the harm of gastric wall thickening is serious or not is closely related to the primary disease, so it is recommended to find out the cause of the disease as soon as possible and target treatment.