Adults with fever can use ibuprofen, acetaminophen, nimesulide and other fever-reducing drugs as prescribed by the doctor, due to individual differences, it is impossible to compare which drug is better. 1. Ibuprofen: a non-steroidal anti-inflammatory drug that can inhibit cyclo-oxygenase and reduce prostaglandin synthesis to achieve anti-inflammatory and antipyretic effects. It is prohibited for allergic people and may cause nausea, vomiting, rash and other adverse reactions after taking it. 2. Acetaminophen: It is a non-steroidal anti-inflammatory drug, which can inhibit the production of prostaglandins and has antipyretic and analgesic effects. Severe hepatic and renal insufficiency, allergic patients are prohibited, may cause renal failure, hepatitis and other adverse reactions. 3. Nimesulide: also belongs to non-steroidal anti-inflammatory drugs, can inhibit prostaglandin synthesis, the release of leukocyte mediators, so as to achieve the effect of lowering body temperature. Allergy, gastrointestinal bleeding, heart failure, severe hepatic and renal insufficiency and other patients are prohibited, may cause heartburn, nausea, stomach pain, abdominal pain and other adverse reactions. Adults should go to the hospital in time after the fever, under the guidance of the doctor to choose the appropriate drug treatment.