Failure to administer the rabies vaccine after two doses will affect the effectiveness of the vaccine and may pose a risk. The rabies vaccine is generally divided into three, four and five shots. After exposure to the rabies virus, it is necessary to follow the requirements of the immune response within a specified period of time to receive rabies vaccine in sufficient quantities and in full in order to produce effective immunity and ensure the preventive effect of the vaccine. If the rabies vaccine is not given after two shots, it may not produce enough antibodies to achieve complete prevention and affect the effectiveness of the vaccine. Rabies is a malignant infectious disease that can only be prevented but not treated, and once it occurs, it can be extremely lethal. Therefore, the behavior of not taking rabies vaccine after two injections may pose a threat to the patient’s life and cause a certain degree of danger. Rabies vaccination must be strictly in accordance with the guidance of a professional doctor, do not blindly do it on your own.