Medications for toothache do not usually cause insomnia, and most medications have adverse reactions such as dizziness, nausea, and gastrointestinal discomfort. However, toothache itself may cause insomnia, and it is recommended to treat the dental disease in time and follow the doctor’s instructions for medication. The main medications used to treat toothache are nitroimidazoles, such as metronidazole and tinidazole, etc. The main side effects of these medications are dizziness, nausea, vomiting, and possible gastrointestinal irritation and other reactions. Antibiotic drugs for toothache such as cephalosporin or penicillin, the main side effects are hives, diarrhea, nausea and other symptoms, and individuals may experience severe allergic reactions. Pain relievers such as ibuprofen, acetaminophen, etc., the main side effects are that there will be gastrointestinal ulcers, loss of appetite, dry mouth and other symptoms, and generally do not appear insomnia. Tooth pain should be timely local clinic to treat dental disease, drugs for supporting role, and should be used under the guidance of a physician.