How long it takes for high urinary protein to come down with medication needs to be decided according to the cause and severity of the patient’s illness, which may be several days or months, or even impossible to come down. If the high urine protein is caused by physiological conditions such as strenuous exercise, late night, high protein diet, etc., generally no medication is needed, and can be reduced to normal in a few days; if it is caused by urinary tract infections, such as cystitis, urethritis, etc., it may be possible to reduce to normal after a few days of taking antibiotics, and the antibiotics can be selected from levofloxacin, cefuroxime, etc.. However, if the high urine protein is caused by glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, etc., how long the urine protein can be reduced needs to be decided according to the specific cause and the degree of urine protein, if it is a small lesion of nephropathy, generally after a few days or even a few months can be reduced; if it is a diabetic nephropathy with a large amount of proteinuria, hypertensive nephropathy, the urine protein may not be able to come down. If you find high urinary protein in clinic, it is recommended to consult the nephrology department of regular hospitals in time to find out the cause and follow the doctor’s instructions to carry out standardized treatment, and the above mentioned medication should be used according to the doctor’s instructions, and should not be used without authorization, so as not to aggravate the condition.