Mild thickening of the pleura of the apical pleura of both lungs is often associated with pneumonia, pleurisy, tuberculosis and other diseases, and it is recommended that general treatment and medication be taken to relieve the symptoms according to the cause of the disease. 1. Pneumonia: Inflammatory edema will be formed when lung tissue is infected with microorganisms, and pleural thickening will be found through examination. Oral antibiotics should be taken as soon as possible to reduce the inflammation, should be combined with the type of causative organisms and rational drug selection, such as oral cefixime, cefaclor to inhibit bacteria; oral metronidazole, tinidazole to inhibit anaerobic bacteria and so on. 2. Pleurisy: When there is inflammation in the pleura, causing pleural effusion, it will lead to mild thickening of the pleura. If the effusion is formed, it is recommended to perform thoracentesis as soon as possible, and then take oral ceftriaxone sodium, cefaclor to inhibit bacteria; if it is caused by Mycobacterium tuberculosis, it can be oral isoniazid, rifampicin anti-tuberculosis. 3. Tuberculosis: when the lung tissue is infected with Mycobacterium tuberculosis and repeatedly stimulated, causing inflammatory edema, there will be inflammatory exudate fluid, which will lead to thickening of the apical pleura of both lungs. The disease is mainly treated by inhibiting Mycobacterium tuberculosis as the principle of treatment, and isoniazid, rifampicin, etc. can be chosen. Double lung apical pleural thickening, may also be old lesions, the disease does not require special treatment, regular observation can be. At present, regular review is needed to clarify the cause of the disease and then follow the doctor’s instructions for targeted treatment, not unauthorized use of drugs.