Acute mastitis and inflammatory breast cancer have the following differences: different clinical manifestations, different anti-inflammatory effects, and different treatment methods. 1. Different clinical manifestations: acute mastitis is usually confined to a certain area of the breast, and the localized area usually does not have an orange peel appearance, often accompanied by redness, swelling and heat pain, while inflammatory breast cancer has relatively extensive lesions, which may have an orange peel appearance, and usually does not have redness and swelling. 2. Different anti-inflammatory effect: after acute mastitis, anti-infection treatment is very effective, but if inflammatory breast cancer, anti-infection treatment usually has no obvious effect. 3. Different treatment methods: if acute mastitis, antibiotics need to be applied; if inflammatory breast cancer, surgery, chemotherapy, radiotherapy and so on are needed. Meanwhile, acute mastitis is commonly found in lactating women, both of which can be clearly diagnosed through pathologic examination. It is recommended that patients go to the hospital, you can improve the relevant examination, after a clear diagnosis under the guidance of the doctor standardized treatment.