Persistent pain in the fossa of the heart for two days is considered to be related to heart disease, gastroesophageal disease and mental illness. 1. Heart disease: pain is generally causative, mostly related to exertion, emotional stress, excitement, strenuous exercise and other increased myocardial oxygen consumption, blood and oxygen are not timely and adequate supply, resulting in insufficient blood supply to the myocardium, which may trigger angina attacks. 2. Gastroesophageal diseases: For example, there are reflux esophagitis, gastritis, gastric ulcer, etc. Gastroesophageal reflux is caused by the relaxation of cardia sphincter due to various factors, which leads to the reflux of gastric contents into the esophagus, and pain occurs, which is usually accompanied by acid reflux, heartburn and a series of clinical manifestations. 3. Psychiatric disorders: the symptoms of cardiac pain are seen when there is no clear organic lesion, and it is a mental problem, such as anxiety, depression showing somatization. If the pain persists and cannot be relieved, you should go to the hospital in time, so as not to delay the condition of the body to cause damage.