Lumbar spondylolisthesis and lumbar disc herniation are two different diseases, and you can choose general treatment, medication, and surgery to relieve symptoms according to different diseases. 1. Lumbar spondylolisthesis: Oral non-steroidal anti-inflammatory drugs can be taken for analgesia, such as celecoxib and ibuprofen. When cauda equina syndrome occurs or causes numbness in the lower limbs, surgical treatment can be considered, such as total decompression of the vertebral plate, lumbar interbody fusion via intervertebral foramen approach, and so on. 2. Lumbar intervertebral disc herniation: bed rest and lumbar protection are needed during acute attack; when the pain is strong, oral non-steroidal anti-inflammatory drugs for pain relief, such as ibuprofen and celecoxib, etc., are recommended. If nerve root edema occurs, then reduce the degree of edema through intravenous input of mannitol. For patients with more severe lumbar disc herniation, surgical treatment can be considered, and the more commonly used surgical methods include spinal endoscopic disc nucleus pulposus removal, simple interlaminar windowing nucleus pulposus removal, and so on. For patients with lumbar spondylolisthesis and lumbar disc herniation, it is necessary to combine the severity and progress of the disease to choose the best treatment, and specific should follow the doctor’s instructions.