The glomerular filtration rate of 157ml/min is high and more serious, suggesting possible acromegaly, gigantism, early diabetic nephropathy and so on. 1. Acromegaly: the normal value of total glomerular filtration rate is (100±20) ml/min. Acromegaly is a disease caused by over secretion of growth hormone, which is often caused by growth hormone adenoma. It is more serious and should be treated in time. 2. Gigantism: due to excessive secretion of growth hormone leading to abnormal development of adolescents, more serious, should be treated promptly. 3. Early diabetic nephropathy: the early stage of diabetes mellitus is characterized by glomerular hyperfiltration. In order to prevent diabetic nephropathy from continuing to deteriorate, treatment should be started in time. If you find that the glomerular filtration rate increases, you should go to the hospital in time to clarify the cause of the disease and follow the doctor’s instructions to standardize the treatment.