Patients sleeping with swollen eyes are usually caused by physiologic factors, allergies, or infections. In addition, kidney failure, heart failure and other systemic diseases can also cause patients with swollen eyes. 1. Physiological factors: if the patient sleeps for a long time to keep the side lying position or prone position, the eyes are compressed, the patient sleeps after the eyes can appear swollen, usually after resting can be relieved. 2. Allergic factors: if allergic patients sleep in contact with bedding attached to the skin debris, mites, cotton wool and other allergens, triggering an allergic reaction, can cause the patient’s eyes swollen, but also itchy eyes and other uncomfortable symptoms. 3. Infection factors: If the bedding is not hygienic, change and wash diligently, resulting in sleeping, the patient’s eye skin contact with contaminated bedding triggered by infections, such as blepharitis, the patient may appear eyelid redness and swelling, eye pain and other uncomfortable symptoms. In addition, patients with kidney failure, heart failure and other systemic diseases, because of the body’s water retention, eyelid edema, may also be accompanied by lower limb edema and other symptoms. It is recommended that patients with significant eyelid swelling and other discomforts should seek medical attention to evaluate their condition and follow the doctor’s instructions for treatment.