Causes of knee effusion include normal physiological effusion, as well as pathological effusion caused by trauma or chronic strain, bacterial infection, tuberculosis bacillus, etc. Non-steroidal drugs, antibiotics, anti-tuberculosis drugs and other medications should be given according to the cause of the disease. 1. Physiological effusion: there is a certain amount of synovial fluid in the knee joint of normal people, about 4 milliliters, which is used to lubricate the joint cavity, and it is a normal physiological phenomenon and does not need to be treated. 2. Caused by trauma or chronic strain: trauma or chronic injury can lead to osteoarthritis, synovitis and other aseptic inflammation, resulting in joint effusion, pain and other clinical symptoms, you can take oral non-steroidal drugs such as diclofenac sodium, celecoxib and so on, for anti-inflammatory and analgesic. 3. Bacterial infection: If the knee joint effusion is caused by bacterial infection, anti-infection treatment is needed, such as cefuroxime sodium, amikacin, vancomycin and other antibiotic treatment, and sensitive antibiotics can also be selected according to the results of drug sensitivity test. 4. caused by tuberculosis: knee tuberculosis can cause joint cavity effusion, need to apply anti-tuberculosis drug treatment, such as isoniazid, rifampicin, pyrazinamide, ethambutol and so on, in order to improve the situation of effusion. If the knee effusion, the patient should actively cooperate with the doctor for examination, clear cause and then targeted treatment, the above drugs need to be used under the guidance of a doctor, avoid blindly use their own drugs.