Monkeypox virus infection in humans may present with chills, fever, swollen lymph nodes, rash, and various secondary complications that may occur. The incubation period after infection with monkeypox virus is 5 to 21 days. Early onset of the disease may be characterized by chills, fever, which is usually above 38.5℃, accompanied by headache, drowsiness, fatigue, back pain and myalgia, etc. In addition to the above symptoms, most of the patients may have a fever in the early stages of the disease. In addition to the above symptoms, most patients may have enlarged lymph nodes in the neck, armpits, groin and other parts of the body. The rash may appear 1-3 days after the onset of the disease, and may start on the face and gradually spread to the limbs and other parts of the body. The rash is more common on the face and extremities than on the trunk, and the number of rashes may vary from a few to several thousand, with the possibility of involvement of the oral mucosa, gastrointestinal tract, and genitals. The rash may progress from macules, papules, herpes, pustules to crusts. Rash in the process of transformation patients can be accompanied by obvious itching and pain, from the onset to the scab off about 2 to 4 weeks later, the scab can be left behind erythema or hyperpigmentation, or even scarring. Some patients may have secondary bacterial infection, bronchopneumonia, encephalitis, corneal infection, sepsis and other complications due to secondary infection of the rash. Once the above symptoms occur, it is necessary to consult a doctor in time, and actively treat the disease after clarifying the cause.